| 產品名稱 | Poziotinib - HM781-36B |
| 產品貨號 | Axon 2920 CAS [1092364-38-9] MF C23H21Cl2FN4O3MW 491.34 Purity: 99% Soluble in DMSO Description Poziotinib is an irreversible pan-HER inhibitor with IC50 values of 0.0032 μM, 0.0053 μM and 0.0235 μM for HER1, HER2 and HER4, respectively. Poziotinib inhibited phosphorylation of HER family and downstream signaling molecules, and induced apoptosis and G1 arrest. Moreover, poziotinib demonstrated potent antitumor activity in HER2 amplified gastric cancer cells, HER2-amplified breast cancer cells, and erlotinib-resistant NSCLC. KEYWORDS: Poziotinib | supplier | HER inhibitor | HM781-36B | CAS [1092364-38-9] | CAS[1429757-68-5] | Non Selective (Phosphorylation Substrates) | EGFR | ErbB2-HER2 | ErbB4-HER4 | Inhibitor | Receptors | Gastric cancer | NSCLC | Breast cancer |
| 產品價格 | 現貨詢價，電話：010-67529703 |
| 產品規格 | |
| 產品品牌 | axonmedchem |
| 產品概述 | |
| 產品詳情 |
Poziotinib - HM781-36BAxon 2920 CAS [1092364-38-9] MF C23H21Cl2FN4O3
DescriptionPoziotinib is an irreversible pan-HER inhibitor with IC50 values of 0.0032 μM, 0.0053 μM and 0.0235 μM for HER1, HER2 and HER4, respectively. Poziotinib inhibited phosphorylation of HER family and downstream signaling molecules, and induced apoptosis and G1 arrest. Moreover, poziotinib demonstrated potent antitumor activity in HER2 amplified gastric cancer cells, HER2-amplified breast cancer cells, and erlotinib-resistant NSCLC. KEYWORDS: Poziotinib | supplier | HER inhibitor | HM781-36B | CAS [1092364-38-9] | CAS[1429757-68-5] | Non Selective (Phosphorylation Substrates) | EGFR | ErbB2-HER2 | ErbB4-HER4 | Inhibitor | Receptors | Gastric cancer | NSCLC | Breast cancer
Irreversible pan-HER inhibitor
Chemical name1-(4-(4-(3,4-Dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)piperidin-1-yl)prop-2-en-1-one Parent CAS No.[1092364-38-9] |
| 產品資料 |
